منابع مشابه
Effects of psychotropic drugs on nerve growth factor protein levels in the rat brain
Introduction: Psychotropic drugs exert their effects, in part, by increasing neurotrophin levels in the brain. Nerve growth factor (NGF) protein levels after treatment with only a limited number of psychotropics have been determined. The present study was designed in order to evaluate the effects of acute and chronic administration of different psychotropic drugs on NGF protein levels in fiv...
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Objective(s):Althoughroutinely applied in assisted reproductive technology, human sperm cryopreservation is not a completely successful procedure. Adverse effects of cryopreservation on the fertilization capacity, motility, morphology, and viability of spermatozoa have been proven; cryopreservation has also shown a role in sperm DNA fragmentation and infertility. The post-thaw survival of sperm...
متن کاملReduced nerve growth factor in Rett syndrome postmortem brain tissue.
To determine whether reduced nerve growth factor (NGF) and/or its high affinity receptor, trkA, play a role in the pathophysiology of Rett syndrome (RS), we used immunohistochemistry in paraffin-embedded human autopsy brain tissue, to quantify NGF and trkA levels within the frontal cortex of 9 RS females and 10 female controls of similar age. The results showed a significant reduction of NGF ex...
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This article provides an overview of different brain insults leading to induction of astroglial NGF expression. It discusses mechanisms of induction of astroglial NGF in a damaged brain and a possible role of its expression in pathophysiology of Alzheimer's disease. It emphasizes that the pharmacological manipulation of astroglial production of NGF may serve as a possible therapeutic strategy t...
متن کاملCo-expression of recombinant human nerve growth factor with trigger factor chaperone in E. coli
Nerve growth factor (NGF) is a neurotrophic factor that is functional in the survival, maintenance and differentiation of nervous system cells. This protein has three subunits, of which the beta subunit has the main activity. Its structure consists of a cysteine knot motif made up of beta strands linked by disulfide bonds. It can be used as a therapeutic agent in the treatment of many diseases....
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ژورنال
عنوان ژورنال: Biomedical Reviews
سال: 2018
ISSN: 1314-1929,1310-392X
DOI: 10.14748/bmr.v29.5845